A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron
Yuan, T. Z.; Lucas, C.; Monteiro, V. S.; Iwasaki, A.; Yang, M. L.; Nepita, H. F.; Lujan Hernandez, A. G.; Taft, J. M.; Frei, L.; Reddy, S. T.; Weber, C.; Malobisky, K. P.; Mesquita, R.; Sato, A.
Show abstract
Bispecific antibodies have emerged as a promising strategy for curtailing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune escape. This brief report highlights RBT-0813 (also known as TB493-04), a synthetic, humanized, receptor-binding domain (RBD)-targeted bispecific antibody that retains picomolar affinity to the Spike (S) trimers of all major variants of concern and neutralizes both SARS-CoV-2 Delta and Omicron in vitro.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative 95%
- Development of a thermostable and broadly neutralizing pan-sarbecovirus vaccine candidate 94%
- Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19 94%
Similar papers in this journal
- Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment 95%
- Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies 95%
- Designing monomeric IFNγ: the significance of domain-swapped dimer structure in IFNγ immune responses 94%
Similar papers in this journal
- A novel biparatopic antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy 96%
- Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological and pathological disease in a Syrian hamster model of COVID-19 96%
- Development of Potent and Effective Synthetic SARS-CoV-2 Neutralizing Nanobodies 96%
Similar papers in this journal
- Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis 95%
- Development of an Escape-resistant SARS CoV-2 Neutralizing Synthetic Nanobody 95%
- A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.