Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breastfeeding
Sajadi, M. M.; Shokatpour, N.; Bathula, A.; Tehrani, Z.; Lankford, A.; Purcell, M.; Campbell, J. D.; Hammershaimb, E. A. D.; Deatrick, K. B.; Bor, C.; Parsell, D. M.; Dugan, C.; Levine, A.; Ramelli, S. C.; Chertow, D.; Herr, D. L.; Lewis, G. K.; Grazioli, A.
Show abstract
Although there have been many studies on antibody responses to SARS-CoV-2 in breastmilk, very few have looked at the fate of these in the baby. We carried out a study in 22 mother/baby pairs (mothers who breastfed and who were SARS-CoV-2 vaccinated before or after delivery) looking at mother blood, mother milk, baby blood, baby nose, and baby stool. Breastfed infants only acquired systemic anti-SARS-CoV-2 IgG antibodies if their mothers were vaccinated antepartum. None of the infants had SARS-CoV-2-specific IgA in the blood, but surprisingly, half of the infants in the Antepartum group had high titer SARS-CoV-2-specific IgA in the nose that exceeded titers found in breastmilk. Vaccination antepartum followed by breastfeeding appears to be the best way to provide systemic and local anti-SARS-CoV-2 antibodies for infants.
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