TRPA1: A Potential Prognostic Indicator for Oral Squamous Cell Carcinoma
Chakraborty, R.; Jabeen, A.; Hu, H.; Darido, C.; Vickery, K.; Ranganathan, S.
Show abstract
IntroductionTransient receptors are related to oral cancer pain. Previously capsaicin (TRPV1 agonist) was shown to induce cell death in oral cancer cells. We hypothesised that these receptors are present in oral cancer. MethodWe examined the presence of cannabinoid receptors (CB1 and CB2) and targets (TRPV1, TRPA1, CaV 3.1, CaV 3.2, CaV 3.3) via quantitative polymerase chain reaction (qPCR) in oral cancer cells SCC4, SCC9, SCC25, Cal27, and normal oral cell line OKF6. ResultCannabinoid receptors are absent in all the cell lines, while TRPA1 is only present in normal cells, but absent in all the oral cancer cell lines. Voltage-gated calcium channels are present in all the cell lines. Conclusion and Future AspectsTRPA1 could be the possible future prognostic indicator of oral squamous cell carcinoma. Future functionality assays could use precancerous cell lines to follow the loss of TRPA1.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Burnout: A Predictor Of Oral Health Impact Profile Among Nigerian Early Career Doctors 95%
- Highly Efficient Antibiofilm and Antifungal Activity of Green Propolis against Candida species in dentistry material 94%
- Pterostilbene Protects Cochlea from Ototoxicity in Streptozotocin-Induced Diabetic Rats by Inhibiting the Apoptosis 94%
Similar papers in this journal
- Evaluation of RNA extraction free method for detection of SARS-COV-2 in salivary samples for mass screening for COVID-19 94%
- Magnesium Sulfate Attenuates Lethality and Oxidative Damage Induced by Different Models of Hypoxia in Mice 92%
- Expression of nitric oxide synthase and nitric oxide levels in peripheral blood cells and oxidized low-density lipoprotein levels in saliva as early markers of severe dengue 92%
Similar papers in this journal
Similar papers in this journal
- MAP Kinase and mammalian target of rapamycin are main pathways of gallbladder carcinogenesis: Results from bioinformatic analysis of Next Generation Sequencing data from a hospital-based cohort. 94%
- A protocol for good quality genomic DNA isolation from formalin-fixed paraffin-embedded tissues without using commercial kits 91%
- Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review 90%
Similar papers in this journal
- Detailed Analysis of Surface Infection Barrier on Hands: Relationship with Morbidity to Infection Diseases and Identification of Antimicrobial Components 94%
- Effects of different environmental intervention durations on the intestinal mucosal barrier and the brain-gut axis in rats with colorectal cancer 93%
- Enhanced expression of Dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including Diaphragm of mdx mice after oral administration of Neu REFIX Beta 1,3-1,6 glucan 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.