Back

Group size planning of breedings of gene-modified animals

Milchevskaya, V.; Bugnon, P.; ten Buren, E. B. J.; Brand, F.; Tresch, A.; Buch, T.

2021-09-20 bioinformatics
10.1101/2021.09.17.460764 bioRxiv
Show abstract

Animal breeding is time-consuming, costly, and affected by stochastic events related to Mendelian genetics, fertility, and litter size. Careful planning is mandatory to ensure a successful outcome using the least number of animals, hence adhering to the 3Rs of animal welfare. We have developed an R package, accessible also through an interactive website, that optimizes breeding design and provides a comprehensive report suitable for any breeder of genetically defined traits.

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

1
Nature Communications
○ 5641 papers in training set
Top 11%
15.3%
Similar papers in this journal
2
Cell Reports Methods
○ 165 papers in training set
Top 0.1%
12.8%
Similar papers in this journal
3
eLife
● 5828 papers in training set
Top 13%
8.0%
Similar papers in this journal
4
Scientific Reports
○ 3612 papers in training set
Top 6%
8.0%
Similar papers in this journal
5
iScience
○ 1154 papers in training set
Top 3%
4.4%
Similar papers in this journal
6
PLOS Biology
● 486 papers in training set
Top 1%
3.6%
50% of probability mass above
7
Communications Biology
○ 993 papers in training set
Top 5%
3.3%
8
BMC Biology
○ 265 papers in training set
Top 0.7%
3.3%
9
Molecular Biology and Evolution
◐ 542 papers in training set
Top 3%
2.5%
10
Current Biology
○ 665 papers in training set
Top 5%
2.5%
11
Nature Computational Science
○ 55 papers in training set
Top 0.4%
2.1%
12
Nature Methods
○ 385 papers in training set
Top 4%
2.1%
13
NAR Genomics and Bioinformatics
◐ 242 papers in training set
Top 2%
2.1%
14
Nucleic Acids Research
◐ 1281 papers in training set
Top 8%
1.7%
15
Genome Biology
○ 637 papers in training set
Top 6%
1.7%
16
Science Advances
● 1243 papers in training set
Top 20%
1.7%
17
PNAS Nexus
◐ 159 papers in training set
Top 2%
1.4%
18
Bioinformatics
◐ 1204 papers in training set
Top 8%
1.1%
19
Disease Models & Mechanisms
139 papers in training set
Top 2%
1.0%
20
Briefings in Bioinformatics
◐ 354 papers in training set
Top 6%
1.0%
21
F1000Research
○ 88 papers in training set
Top 3%
1.0%
22
PLOS ONE
● 5266 papers in training set
Top 57%
0.9%
23
Genome Research
● 468 papers in training set
Top 6%
0.9%
24
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 40%
0.9%
25
Science
● 477 papers in training set
Top 10%
0.6%
26
BMC Bioinformatics
○ 457 papers in training set
Top 6%
0.6%
27
PLOS Computational Biology
● 1863 papers in training set
Top 21%
0.6%
28
Cell Genomics
○ 172 papers in training set
Top 5%
0.6%
29
Development
● 497 papers in training set
Top 5%
0.6%
30
Molecular Systems Biology
○ 162 papers in training set
Top 4%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.