Simultaneous Cardiac and Neurological Monitoring to Assess Chemical Exposures and Drug Toxicity in Xenopus Laevis
Xia, X.; Zhang, J.; Vishwanath, M.; Sarafan, S.; Torres, R. S. T.; Le, T.; Lau, M. P. H.; Nguyen, A. H.; Cao, H.
Show abstract
Simultaneous monitoring of electrocardiogram (ECG) and electroencephalogram (EEG) under chemical exposure requires innovative engineering techniques that can capture minute physiological changes in studied animal models. However, this is often administered with a bulky system that may cause signal distortions and discomfort for animals. We develop an integrated bioelectronic sensing system to provide simultaneous ECG and EEG assessment in real-time under chemical exposure for Xenopus laevis. The microelectrode array (MEA) membrane with integrated ECG and EEG sensing offers an opportunity to achieve multichannel noninvasive electrophysiological monitoring with favorable dimensions and spatial resolution. To validate the performance of our system, we assessed the ECG and EEG of Xenopus under exposure of Pentylenetetrazol (PTZ), an epilepsy-inducing drug. Effects of PTZ were detected with clear ECG and EEG alterations, including frequent ictal and interictal EEG events, 30 dB average EEG amplitude elevations, abnormal ECG morphology, and heart rate changes. Overall, our Xenopus-based real-time electrophysiology monitoring system holds high potential for many applications in drug screening and remote environmental toxicity monitoring.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Dynamic Multiday Seizure Cycles in a Tetanus Toxin Rat Model of Epilepsy: Evolving Rhythms and Implications for Prediction 94%
- EEG-based diagnostics of the auditory system using cochlear implant electrodes as sensors 93%
- Automated methodology for optimal selection of the minimum electrode subset for accurate EEG source estimation based on Genetic Algorithm optimization 92%
Similar papers in this journal
Similar papers in this journal
- CardioMEA: Comprehensive Data Analysis Platform for Studying Cardiac Diseases and Drug Responses 92%
- Effective Assessments of a Short-duration Poor Posture on Upper Limb Muscle Fatigue before Physical Exercise 91%
- Occurrence of relative bradycardia and relative tachycardia in individuals diagnosed with COVID-19 90%
Similar papers in this journal
- CluSem: Accurate Clustering-based Ensemble Methodto Predict Motor Imagery Tasks from Multi-channelEEG Data 93%
- A surface metric and software toolbox for EEG electrode grids in the macaque 92%
- A convolutional-recurrent neural network approach to resting-state EEG classification in Parkinson’s disease 92%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.