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In vitro antimicrobial and cytotoxic activity of Lippia origanoides essential oil against bacteria of potential health concern

Quiguanas Guarin, E. S.; Agudelo, J. P. B.; Lopez-Carvajal, J. E.; Tabares, Y. A. R.; Sanabria, L. P.; Castano-Osorio, J. C.

2021-09-02 microbiology
10.1101/2021.09.02.458771 bioRxiv
Show abstract

Due to the growing resistance they develop of bacteria to drugs, the search for alternatives in natural products is considered important such as Lippia origanoides essential oil. Here, the antibacterial activity of the oil and two of its major chemical components were tested against bacteria of potential health concern. The cytotoxicity of these compounds was evaluated in human erythrocytes and Vero cells. 51 compounds were identified in the LOEO, being terpinen-4-ol, {gamma}-Terpinene, citronellal and thymol the main. LOEO and thymol showed antibacterial activity from 904 g/mL and 200 g/mL, respectively. {gamma}-Terpinene did not show activity any concentration tested. LOEO showed hemolysis at concentration of 3000 g/mL and thymol at 100 g/mL. LOEO and thymol showed cytotoxicity in the evaluated cell lines at 250 g/mL and 100 g/mL, respectively. These compounds have a moderate cytotoxicity so its considered necessary to study alternatives to reduce the in vitro cytotoxicity of these compounds. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=103 SRC="FIGDIR/small/458771v1_ufig1.gif" ALT="Figure 1"> View larger version (20K): org.highwire.dtl.DTLVardef@12a1b81org.highwire.dtl.DTLVardef@173b4cdorg.highwire.dtl.DTLVardef@16306a7org.highwire.dtl.DTLVardef@49fa26_HPS_FORMAT_FIGEXP M_FIG C_FIG

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