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Pattern of variation in DNA methylation during pregnancy among mothers who delivered preterm in the GARBH-Ini cohort
2021-09-10
genetic and genomic medicine
Title + abstract only
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BackgroundDNA methylation (DNAm) may play an important role in birth outcomes. Material and MethodsGenome wide DNAm was analysed in peripheral blood DNA of women at multiple time points during gestation. A novel empirical method was used to identify CpG sites with high temporal variance in methylation associating with preterm birth. ResultsHigh variability at 1296 CpG sites from the promoter regions of 1197 genes significantly associated with PTB. These genes belonged to pathways involved in s...
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