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An AAV-ie based Vaccine effectively protects against SARS-CoV-2 and Circulating Variants

Zhao, S.; Tan, F.; Ke, J.; Yang, J.; Lin, C.-b.; Wang, H.; zhong, g.

2021-05-20 microbiology
10.1101/2021.05.19.444889 bioRxiv
Show abstract

Prophylactic vaccines against SARS-CoV-2 have been extensively developed globally to overcome the COVID-19 pandemic. However, recently emerging SARS-CoV-2 variants B.1.1.7 and B.1.351 limit the vaccine protection effects and successfully escape antibody cocktail treatment. Herein, based on our previously engineered adeno-associated viral (AAV) vector, AAV-ie, and systematic immunogen screening, we developed an AAV-ie-S1 vaccine with thermostability, high efficiency, safety, and single-dose vaccination advantage. Importantly, the AAV-ie-S1 immune sera efficiently neutralize B.1.1.7 and B.1.351, indicating a potential to circumvent the spreading of SARS-CoV-2.

Matching journals

The top 9 journals account for 50% of the predicted probability mass.

1
eLife
● 5828 papers in training set
Top 8%
11.6%
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2
Nature Communications
○ 5641 papers in training set
Top 19%
9.6%
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3
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Top 1.0%
7.7%
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4
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○ 50 papers in training set
Top 0.1%
6.1%
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5
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6
Proceedings of the National Academy of Sciences
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Top 14%
3.9%
7
iScience
○ 1154 papers in training set
Top 8%
3.2%
8
Vaccine
○ 203 papers in training set
Top 0.9%
3.1%
9
Molecular Therapy Methods & Clinical Development
○ 13 papers in training set
Top 0.1%
2.7%
50% of probability mass above
10
Viruses
○ 332 papers in training set
Top 2%
2.6%
11
Frontiers in Immunology
○ 638 papers in training set
Top 5%
2.4%
12
npj Vaccines
○ 67 papers in training set
Top 0.4%
2.3%
13
Microbiology Spectrum
● 469 papers in training set
Top 6%
2.1%
14
PLOS ONE
● 5266 papers in training set
Top 43%
2.1%
15
PLOS Pathogens
● 820 papers in training set
Top 6%
2.1%
16
Science Advances
● 1243 papers in training set
Top 17%
2.1%
17
Journal of Medical Virology
○ 140 papers in training set
Top 1%
1.9%
18
Emerging Microbes & Infections
○ 74 papers in training set
Top 0.7%
1.7%
19
Molecular Therapy
○ 81 papers in training set
Top 0.9%
1.7%
20
Protein & Cell
◐ 25 papers in training set
Top 0.2%
1.6%
21
Scientific Reports
○ 3612 papers in training set
Top 57%
1.5%
22
mBio
● 833 papers in training set
Top 8%
1.4%
23
Science Bulletin
○ 21 papers in training set
Top 0.3%
1.1%
24
eBioMedicine
○ 183 papers in training set
Top 5%
1.1%
25
Journal of Molecular Cell Biology
◐ 22 papers in training set
Top 0.2%
1.0%
26
Molecular Therapy - Methods & Clinical Development
○ 38 papers in training set
Top 0.6%
1.0%
27
Science China Life Sciences
○ 29 papers in training set
Top 0.4%
1.0%
28
Cell Research
○ 51 papers in training set
Top 1%
1.0%
29
Cell Reports
○ 1498 papers in training set
Top 25%
1.0%
30
Cell & Bioscience
○ 14 papers in training set
Top 0.2%
0.8%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.