Dietary restriction and clock delay eye aging to extend lifespan in D. melanogaster
Hodge, B. A.; Meyerhof, G. T.; Katewa, S. D.; Lian, T.; Lau, C.; Bar, S.; Leung, N.; Li, M.; Li-Kroeger, D.; Melov, S.; Schilling, B.; Montell, C.; Kapahi, P.
Show abstract
Many vital processes in the eye are under circadian regulation, and circadian dysfunction has emerged as a potential driver of eye aging. Dietary restriction is one of the most robust lifespan-extending therapies and amplifies circadian rhythms with age. Herein, we demonstrate that dietary restriction extends lifespan in D. melanogaster by promoting circadian homoeostatic processes that protect the visual system from age- and light- associated damage. Disrupting circadian rhythms in the eye by inhibiting the transcription factor, Clock (CLK), or CLK-output genes, accelerated visual senescence, induced a systemic immune response, and shortened lifespan. Flies subjected to dietary restriction were protected from the lifespan-shortening effects of photoreceptor activation. Inversely, photoreceptor inactivation, achieved via mutating rhodopsin or housing flies in constant darkness, primarily extended lifespan in flies reared on a high-nutrient diet. Our findings establish the eye as a diet-sensitive modulator of lifespan and indicate that vision is an antagonistically pleiotropic process that contributes to organismal aging.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons 95%
- Muscle function and homeostasis require macrophage-derived cytokine inhibition of AKT activity in Drosophila 95%
- Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans 95%
Similar papers in this journal
- Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans 95%
- Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging 94%
- The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth 94%
Similar papers in this journal
Similar papers in this journal
- Upstream open reading frames dynamically modulate CLOCK protein translation to regulate circadian rhythm and sleep 94%
- The Drosophila Amyloid Precursor Protein homologue mediates neuronal survival and neuro-glial interactions 94%
- Transcription-induced formation of extrachromosomal DNA during yeast ageing 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.