Characterizing cellular and molecular variabilities of peripheral immune cells in healthy inactivated SARS-CoV-2 vaccine recipients by single-cell RNA sequencing
Tong, R.; Zhong, J.; Li, R.; Chen, Y.; Hu, L.; Li, Z.; Shi, J.; Lin, G.; Lyu, Y.; Hu, L.; Guo, X.; Liu, Q.; Shuang, T.; Zhang, C.; Yuan, A.; Zhang, M.; Lin, W.; Pu, J.
Show abstract
We systematically investigated the transcriptomes of the peripheral immune cells from 6 inactivated vaccine, BBIBP-CorV recipients at 4 pivotal time points using single-cell RNA-seq technique. First, the significant variation of the canonical immune-responsive signals of both humoral and cellular immunity, as well as other possible symptom-driver signals were evaluated in the specific cell types. Second, we described and compared the common and distinct variation trends across COVID-19 vaccination, disease progression, and flu vaccination to achieve in-depth understandings of the manifestation of immune response in peripheral blood under different stimuli. Third, the expanded T cell and B cell clones were correlated to the specific phenotypes which allowed us to characterize the antigen-specific ones much easier in the future. At last, other than the coagulopathy, the immunogenicity of megakaryocytes in vaccination were highlighted in this study. In brief, our study provided a rich data resource and the related methodology to explore the details of the classical immunity scenarios.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine 96%
- One year landscape of the inactivated virus vaccine triggered RBD-specific IgG, IgM and IgA responses against the Omicron variant 96%
- Disease associated human TCR characterization by deep-learning framework TCR-DeepInsight 94%
Similar papers in this journal
- Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single cell sequencing 95%
- A spatial and cellular distribution of neurotropic virus infection in the mouse brain revealed by fMOST and single cell RNA-seq 93%
- Vaccine-breakthrough infection by the SARS-CoV-2 Omicron variant elicits broadly cross-reactive immune responses 92%
Similar papers in this journal
- An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants 92%
- Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection 92%
- SARS-CoV-2-Triggered Mast Cell Rapid Degranulation Induces Alveolar Epithelial Inflammation and Lung Injury 92%
Similar papers in this journal
- BCR, not TCR, repertoire diversity is associated with favorable COVID-19 prognosis 94%
- A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD 94%
- Impact of SARS-CoV-2 vaccination on systemic immune responses in people living with HIV 94%
Similar papers in this journal
- Genetic immune response and antibody repertoire of heterologous ChAdOx1-BNT162b2 vaccination in a Korean cohort 96%
- SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response 94%
- A Chinese host genetic study discovered type I interferons and causality of cholesterol levels and WBC counts on COVID-19 severity 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.