Back

Lives Saved from Age-Prioritised COVID-19 Vaccination

Goldstein, J. R.; Mahmud, A.; Cassidy, T.

2021-03-22 epidemiology
10.1101/2021.03.19.21253991 medRxiv
Show abstract

BACKGROUNDThe criteria used to allocate scarce COVID-19 vaccines are hotly contested. While some are pushing just to get vaccines into arms as quickly as possible, others advocate prioritization in terms of risk. OBJECTIVEOur aim is to use demographic models to show the enormous potential of vaccine risk-prioritization in saving lives. METHODSWe develop a simple mathematical model that accounts for the age distribution of the population and of COVID-19 mortality. This model considers only the direct live-savings for those who receive the vaccine, and does not account for possible indirect effects of vaccination. We apply this model to the United States, Japan, and Bangladesh. RESULTSIn the United States, we find age-prioritization would reduce deaths during a vaccine campaign by about 93 percent relative to no vaccine and 85 percent relative to age-neutral vaccine distribution. In countries with younger age structures, such as Bangladesh, the benefits of age-prioritization are even greater. CONTRIBUTIONFor policy makers, our findings give additional support to risk-prioritized allocation of COVID-19 vaccines. For demographers, our results show how the age-structures of the population and of disease mortality combine into an expression of risk concentration that shows the benefits of prioritized allocation. This measure can also be used to study the effects of prioritizing other dimensions of risk such as underlying health conditions.

Matching journals

The top 7 journals account for 50% of the predicted probability mass.

1
Journal of Theoretical Biology
162 papers in training set
Top 0.1%
17.1%
2
Demographic Research
11 papers in training set
Top 0.1%
12.0%
3
PLOS ONE
5266 papers in training set
Top 24%
6.8%
4
Journal of The Royal Society Interface
235 papers in training set
Top 0.6%
5.6%
5
Proceedings of the National Academy of Sciences
2444 papers in training set
Top 16%
3.3%
6
Scientific Reports
3612 papers in training set
Top 32%
3.3%
7
PLOS Computational Biology
1863 papers in training set
Top 10%
3.3%
50% of probability mass above
8
Mathematical Biosciences
49 papers in training set
Top 0.3%
3.2%
9
Royal Society Open Science
214 papers in training set
Top 1%
3.2%
10
Mathematical Medicine and Biology: A Journal of the IMA
10 papers in training set
Top 0.1%
2.8%
11
Infectious Disease Modelling
54 papers in training set
Top 0.6%
2.5%
12
eLife
5828 papers in training set
Top 40%
2.5%
13
Epidemiology
32 papers in training set
Top 0.2%
2.4%
14
Vaccine
203 papers in training set
Top 1%
2.1%
15
PNAS Nexus
159 papers in training set
Top 1%
1.4%
16
Epidemiology and Infection
89 papers in training set
Top 2%
1.3%
17
Statistics in Medicine
40 papers in training set
Top 0.4%
1.1%
18
Vaccines
198 papers in training set
Top 2%
1.1%
19
Statistical Methods in Medical Research
11 papers in training set
Top 0.1%
1.1%
20
International Journal of Epidemiology
88 papers in training set
Top 2%
0.9%
21
Bulletin of Mathematical Biology
92 papers in training set
Top 1%
0.9%
22
BMC Infectious Diseases
133 papers in training set
Top 5%
0.9%
23
Frontiers in Public Health
148 papers in training set
Top 6%
0.9%
24
Mathematical Biosciences and Engineering
23 papers in training set
Top 0.8%
0.9%
25
Nature Communications
5641 papers in training set
Top 56%
0.9%
26
Science Advances
1243 papers in training set
Top 30%
0.9%
27
Medical Decision Making
12 papers in training set
Top 0.4%
0.9%
28
Biostatistics
24 papers in training set
Top 0.3%
0.8%
29
American Journal of Epidemiology
67 papers in training set
Top 1%
0.6%
30
Physical Biology
46 papers in training set
Top 1%
0.6%