The new Coronavirus (SARS-CoV-2) in Central America: Demographic-spatial simulations, Analyses of Molecular Variance (AMOVA) and Neutrality Tests in complete genomes from Belize, Guatemala, Cuba, Jamaica and Puerto Rico
Ramos, R. d. S.; Venancio, D. B. R.; Da Silva, E. D. A. B.; de Albuquerque, R. M.; Felix, P. T.
Show abstract
In this work, we evaluated the levels of genetic diversity in 38 complete genomes of SARS-CoV-2 from five Central American countries (Belize, Guatemala, Cuba, Jamaica and Puerto Rico) with 04, 10, 2, 8 and 14 haplotypes, respectively, with an extension of up to 29,885 bp. All sequences were publicly available on the National Biotechnology Information Center (NCBI) platform. Using specific methodologies for paired FST, AMOVA, mismatch, demographic-spatial expansion, molecular diversity and for the time of evolutionary divergence, it was possible to notice that only 79 sites remained conserved and that the high number of polymorphisms found helped to establish a clear pattern of genetic non-structuring, based on the time of divergence between the groups. The analyses also showed that significant evolutionary divergences within and between the five countries corroborate the fact that possible rapid and silent mutations are responsible for the increase in genetic variability of the Virus, a fact that would hinder the work with molecular targets for vaccines and medications in general.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- SARS-CoV-2 Genomic Surveillance in Costa Rica: Evidence of a Divergent Population and an Increased Detection of a Spike T1117I Mutation 96%
- E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil 95%
- Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2 94%
Similar papers in this journal
- The Algerian chapter of SARS-CoV-2 pandemic: An evolutionary, genetic, and epidemiological prospect of the first wave 96%
- Tracing SARS-CoV-2 Evolution in Algeria: Insights from 2020-2023 95%
- Emergence of two distinct SARS-CoV-2 Gamma variants and the rapid spread of P.1-like-II SARS-CoV-2 during the second wave of COVID-19 in Santa Catarina, Southern Brazil 94%
Similar papers in this journal
- High prevalence of an alpha variant lineage with a premature stop codon in ORF7a in Iraq, winter 2020-2021 94%
- Whole Genome Sequencing Analysis of Spike D614G Mutation Reveals Unique SARS-CoV-2 Lineages of B.1.524 and AU.2 in Malaysia 94%
- SARS-CoV-2: Proof of recombination between strains and emergence of possibly more virulent ones 94%
Similar papers in this journal
- Genome-based comparison between the recombinant SARS-CoV-2 XBB and its parental lineages 95%
- SARS-CoV-2 genomic monitoring in the Sao Paulo State unveils new sublineages of the AY.43 strain 94%
- A rapid and cost-effective multiplex ARMS-PCR method for the simultaneous genotyping of the circulating SARS-CoV-2 phylogenetic clades 93%
Similar papers in this journal
- Analysis of genome characteristics and transmission of SARS-CoV-2 strains in North-East of Romania during the first COVID-19 outbreak 94%
- Positive selection of ORF3a and ORF8 genes drives the evolution of SARS-CoV-2 during the 2020 COVID-19 pandemic 94%
- Translation-associated mutational U-pressure in the first ORF of SARS-CoV-2 and other coronaviruses 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.