Identification of four linear B-cell epitopes on the SARS-CoV-2 spike protein able to elicit neutralizing antibodies
Li, L.; Zhao, Z.; Yang, X.; Li, W.; Chen, S.; Sun, T.; Wang, L.; He, Y.; Liu, G.; Han, X.; Wen, H.; Liu, Y.; Chen, Y.; Wang, H.; Li, J.; Su, Z.; Chen, D.; Wang, Y.; Li, X.; Yang, Z.; Wang, J.; Li, M.; Wang, T.; Wang, Y.; Fan, Y.; Wang, H.; Zhang, J.
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SARS-CoV-2 unprecedentedly threatens the public health at worldwide level. There is an urgent need to develop an effective vaccine within a highly accelerated time. Here, we present the most comprehensive S-protein-based linear B-cell epitope candidate list by combining epitopes predicted by eight widely-used immune-informatics methods with the epitopes curated from literature published between Feb 6, 2020 and July 10, 2020. We find four top prioritized linear B-cell epitopes in the hotspot regions of S protein can specifically bind with serum antibodies from horse, mouse, and monkey inoculated with different SARS-CoV-2 vaccine candidates or a patient recovering from COVID-19. The four linear B-cell epitopes can induce neutralizing antibodies against both pseudo and live SARS-CoV-2 virus in immunized wild-type BALB/c mice. This study suggests that the four linear B-cell epitopes are potentially important candidates for serological assay or vaccine development.
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