First computational design of Covid-19 coronavirus vaccine using lambda superstrings
Martinez, L.; Malaina, I.; Salcines, D.; Teran, H.; Alegre, S.; MartInez de la Fuente, I.; Gonzalez, E.; Ocejo, G.; Alvarez, C.
Show abstract
In this work we have developed, by employing lambda superstrings, a map of candidate vaccines against SARS-CoV-2 with lengths between 9 and 200, based on estimations of the immunogenicity of the epitopes and the binding affinity of epitopes to MHC class I molecules using tools from the IEDB Analysis Resource, as well as the overall predictions obtained using the VaxiJen tool. We have synthesized one of the peptides, specifically the one of length 22, and we have carried out an immunogenicity assay and a cytokine assay, which has given positive results in both cases.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Immuno-informatics Design of a Multimeric Epitope Peptide Based Vaccine Targeting SARS-CoV-2 Spike Glycoprotein 97%
- Design of multi-epitope vaccine candidate against Brucella type IV secretion system (T4SS) 96%
- Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches 95%
Similar papers in this journal
Similar papers in this journal
- A Multiple Peptides Vaccine against nCOVID-19 Designed from the Nucleocapsid phosphoprotein (N) and Spike Glycoprotein (S) via the Immunoinformatics Approach 96%
- Zika viral proteome analysis reveals an epitope cluster within NS3 helicase as a potential vaccine candidate: an in silico study 96%
- Epitope-Based Peptide Vaccine against Bombali Ebolavirus Viral Protein 40: An Immunoinformatics Combined with Molecular Docking Studies 94%
Similar papers in this journal
- Epitope-based peptide vaccine against glycoprotein G of Nipah henipavirus using immunoinformatics approaches 96%
- Design of Epitope Based Peptide Vaccine Against Pseudomonas Aeruginosa Fructose Bisphosphate Aldolase Protein using Immunoinformatics 96%
- Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain: In silico analysis 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.