Back

Hsp22 is the key sensor and balancer in mitochondrial dynamic associated metabolic reprogramming

Zaiwa, W.; Ying, C.; Xueyi, W.; Wenjing, W.; Ning, T.; Fang, S.; Yafang, T.; Jingxin, M.; Rujia, L.; Tianchan, P.; Yanmei, H.; Quan, Z.; Lili, W.; Liangxian, L.; Xiaoli, W.; Qinghua, L.

2020-11-23 cancer biology
10.1101/2020.11.22.393116 bioRxiv
Show abstract

Altered mitochondrial dynamics are commonly seen in tumors and Parkinsons disease (PD), but the exact mechanism is unclear. We observed in tumor and PD flies, interference of mitochondrial fission or fusion reverses metabolic reprogramming and attenuates pathogenic phenotypes, indicating the rebalanced mitochondrial dynamics can re-establish cellular homeostasis. Surprisingly, we found Hsp22 is highly induced in tumor and PD flies. Hence, Hsp22 overexpression, not only suppressed RAS tumor flies, hepatocellular carcinoma mice, but also rescued PINK1B9 PD flies associating with restored mitochondrial homeostasis and reversing metabolic reprogramming. We speculate that mitochondrial dynamics is normally in a constant dynamic equilibrium, as if on a continually oscillating seesaw, tumor and PD are like the two extreme states of the seesaw which can be corrected by the promising target, Hsp22. One Sentence SummaryMitochondrial dynamics defects including tumor and PD lead to metabolic reprogramming accompanied with Hsp22 induction, vice versa, overexpression of Hsp22 reverses the mitochondrial dynamic dysfunction caused pathogenic metabolism.

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

1
iScience
○ 1154 papers in training set
Top 0.1%
15.1%
Similar papers in this journal
2
Cell Death & Disease
147 papers in training set
Top 0.1%
13.4%
3
eLife
● 5828 papers in training set
Top 7%
12.1%
Similar papers in this journal
4
Cell Death & Differentiation
○ 48 papers in training set
Top 0.1%
4.4%
Similar papers in this journal
5
Cell Reports
○ 1498 papers in training set
Top 11%
3.6%
Similar papers in this journal
6
Aging
○ 75 papers in training set
Top 0.4%
3.3%
50% of probability mass above
7
Redox Biology
○ 70 papers in training set
Top 0.4%
3.2%
8
Nature Communications
○ 5641 papers in training set
Top 37%
2.8%
9
Cell Death Discovery
○ 58 papers in training set
Top 0.2%
2.7%
10
Scientific Reports
○ 3612 papers in training set
Top 40%
2.5%
11
EMBO Reports
○ 263 papers in training set
Top 2%
2.4%
12
Free Radical Biology and Medicine
○ 36 papers in training set
Top 0.3%
1.8%
13
Advanced Biology
○ 29 papers in training set
Top 0.3%
1.5%
14
Experimental Cell Research
○ 28 papers in training set
Top 0.3%
1.5%
15
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
○ 26 papers in training set
Top 0.4%
1.5%
16
PLOS Genetics
● 862 papers in training set
Top 9%
1.1%
17
Cells
○ 249 papers in training set
Top 5%
1.1%
18
Communications Biology
○ 993 papers in training set
Top 20%
1.1%
19
Disease Models & Mechanisms
139 papers in training set
Top 2%
1.1%
20
Acta Neuropathologica Communications
○ 89 papers in training set
Top 2%
1.1%
21
Science Advances
● 1243 papers in training set
Top 27%
1.1%
22
The FEBS Journal
○ 93 papers in training set
Top 2%
0.9%
23
Neurobiology of Disease
○ 148 papers in training set
Top 3%
0.9%
24
Frontiers in Cell and Developmental Biology
○ 233 papers in training set
Top 6%
0.6%
25
PLOS ONE
● 5266 papers in training set
Top 61%
0.6%
26
BMC Biology
○ 265 papers in training set
Top 6%
0.6%
27
International Journal of Molecular Sciences
○ 494 papers in training set
Top 17%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.