Differentiation independent neuroprotective role of Vcan+ oligodendrocyte precursor cells in poststroke cognitive impairment recovery
Shen, S.; Wang, Y.; Xia, R.; Zeng, F.; Cao, J.; Liu, X.; Zhang, Y.; Wang, Z.; Tao, T.
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The cell type-specific molecular pathology of post-stroke cognitive impairment (PSCI) in the hippocampus has not been thoroughly elucidated. We analyzed 27,069 cells by using single-cell RNA sequencing, and four oligodendrocyte precursor cell (OPC) subtypes were identified, Vcan+ OPCs, which were determined to be the primary cluster among them. Additionally, we examined the features of endothelial cells (ECs) and found that Lcn2+ ECs might play neuroprotective roles via Vwf after stroke. These results may facilitate further studies attempting to identify new avenues of research and novel targets for PSCI treatment.
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