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Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

Ahuno, S. T.; Doebley, A.-L.; Ahearn, T. U.; Yarney, J.; Titiloye, N.; Hamel, N.; Adjei, E.; Clegg-Lamptey, J.-N.; Edusei, L.; Awuah, B.; Song, X.; Vanderpuye, V.; Abubakar, M.; Duggan, M.; Stover, D.; Nyarko, K.; Bartlet, J. M. S.; Aitpillah, F.; Ansong, D.; Gardner, K. L.; Boateng, F. A.; Bowcock, A. M.; Caldas, C.; Foulkes, W. D.; Wiafe, S.; Wiafe-Addai, B.; Garcia-Closas, M.; Kwarteng, A.; Ha, G.; Figueroa, J.; Polak, P.; Ghana Breast Health Study Team,

2020-10-27 oncology
10.1101/2020.10.25.20217133 medRxiv
Show abstract

Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. ctDNA was readily detected in 15 blood samples collected in Ghana at the time of suspected breast cancer. Genomic alterations previously associated with unfavorable prognostic outcomes were observed in the majority of patients. This supports the use of liquid biopsies for diagnosis, surveillance and clinical management of breast cancer in Ghana.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.