DPP6 gene in European American Alzheimer s Disease
Kirola, L.; Budde, J. P.; Wang, F.; Norton, J.; Cruchaga, C.; Fernandez, M.-V.
Show abstract
DPP6 encodes a transmembrane protein that expresses highly in the hippocampal regions of the brain and regulates dendritic excitability. Recently, rare and loss of function variants were reported in DPP6 and further demonstrated to be associated with early onset Alzheimer Disease (AD) and frontotemporal dementia. We performed single variant and gene-based analyses in three non-Hispanic white cohorts: a familial late onset AD (cases=1212, controls=341), an unrelated early onset AD (cases=1385, controls=3864) and in the unrelated Alzheimer disease sequencing project (ADSP, cases=5679, controls=4601). Neither single variant or gene-based analysis revealed any significant statistical association of DPP6 variants with the risk for AD in the cohorts examined.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Alzheimer’s disease risk SNPs show no strong effect on miRNA expression in human lymphoblastoid cell lines 96%
- Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease 95%
- Failure to detect synergy between variants in transferrin and hemochromatosis and Alzheimer’s disease in large cohort 95%
Similar papers in this journal
- Module analysis using single-patient differential expression signatures improve the power of association study for Alzheimer's disease 92%
- The effect of Alzheimer’s disease-associated genetic variants on longevity 91%
- Genetic landscape of rare autoinflammatory disease variants in Qatar and Middle Eastern populations through the integration of whole-genome and exome datasets 90%
Similar papers in this journal
- APOE-stratified genome-wide association study suggests potential novel genes for late-onset Alzheimer’s disease in East-Asian descent 94%
- Alzheimer’s Disease variant portal (ADVP): a catalog of genetic findings for Alzheimer’s Disease 94%
- Liver-specific polygenic risk score is more strongly associated than genome-wide score with Alzheimer’s disease diagnosis in a case-control analysis 94%
Similar papers in this journal
- Predicting Lung Cancer in Korean Never-Smokers with Polygenic Risk Scores 87%
- Genome-wide association studies of 27 accelerometry-derived physical activity measurements identified novel loci and genetic mechanisms 86%
- Integrative genomic analysis in African American children with asthma finds 3 novel loci associated with lung function 85%
Similar papers in this journal
- Obesity-related brain atrophy occurs through mechanisms independent of Alzheimer’s disease pathology 94%
- Frequency of Variants in Mendelian Alzheimer’s Disease Genes within the Alzheimer’s Disease Sequencing Project (ADSP) 93%
- Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer’s Disease 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.