COVID19: Exploring uncommon epitopes for a stable immune response through MHC1 binding
Abitogun, F. M.; Srivastava, R.; Sharma, S.; Komarysta, V.; Akurut, E.; Munir, N.; Macalalad, L.; Ojo-Rowland, O.; Owolabi, O.; Giwa, A.; Debnath, S.
Show abstract
The COVID19 pandemic has resulted in 1,092,342 deaths as of 14th October 2020, indicating the urgent need for a vaccine. This study highlights novel protein sequences generated by shot gun sequencing protocols that could serve as potential antigens in the development of novel subunit vaccines and through a stringent inclusion criterion, we characterized these protein sequences and predicted their 3D structures. We found distinctly antigenic sequences from the SARS-CoV-2 that have led to identification of 4 proteins that demonstrate an advantageous binding with Human leukocyte antigen-1 molecules. Results show how previously unexplored proteins may serve as better candidates for subunit vaccine development due to their high stability and immunogenicity, reinforce by their HLA-1 binding propensities and low global binding energies. This study thus takes a unique approach towards furthering the development of vaccines by employing multiple consensus strategies involved in immuno-informatics technique.
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