Quantitative assessment on the severity degree of Alzheimer dementia by algebraic analysis on cortical thickness profiles of human brains
Kim, S.; Park, S.; Chang, I.
Show abstract
Alzheimer disease(AD) affects profoundly the quality of human life. Quantifying the severity degree of Alzheimer dementia for an individual person is critical for the early diagnose and prescription for delaying the further dementia progression. However, the quantitative diagnose for human subjects of the mild cognitively impairment(MCI) or AD with the different degree of dementia severity is a difficult task due to both the very broad distribution of dementia severities and the lack of good quantitative determinant to assess it. Here, based on cortical thickness profiles of human brains measured by magnetic resonance experiment, a new algebraic approach is presented for the personalized quantification of the severity degree of AD, ranging from 0 for the basin of cognitively normal state to 1 for AD state. Now one can unfold the broad distribution of dementia severities and corresponding cortex regions of human brains with MCI or AD by the different severity degree.
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