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Peto odds ratios demonstrate no advantage over classic odds ratios in meta-analysis of binary rare outcomes

2020-10-16 epidemiology Title + abstract only
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In this study, we examined the discrepancy between large studies and small studies in meta-analyses of rare event outcomes and the impact of Peto versus the classic odds ratios (ORs) through empirical data from the Cochrane Database of Systematic Reviews that collected from January 2003 to May 2018. Meta-analyses of binary outcomes with rare events (event rate [≤]5%), with at least 5 studies, and with at least one large study (N[≥]1000) were extracted. The Peto and classic ORs were used as...

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