External validation of the predictive performance of population pharmacokinetic models for phenobarbital in pediatric patients

2020-09-11 pharmacology and therapeutics Title + abstract only

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AimSeveral studies have reported population pharmacokinetic models for phenobarbital (PB), but the predictive performance of these models has not been well documented. This study aims to do external validation of the predictive performance in published pharmacokinetic models. MethodsTherapeutic drug monitoring data collected in neonates and young infants treated with PB for seizure control, was used for external validation. A literature review was conducted through PubMed to identify population...

External validation of the predictive performance of population pharmacokinetic models for phenobarbital in pediatric patients

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