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TGF-β1 in extracellular vesicles from HIV-infected plasma and macrophages linked to cardiopulmonary dysfunction

2020-09-11 respiratory medicine Title + abstract only
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RationaleExtracellular vesicles (EVs) have emerged as important mediators in cell-cell communication and disease pathogenesis; however, their relevance in pulmonary hypertension (PH) secondary to HIV infection is yet to be explored. ObjectiveTo examine the role of circulating small EVs and monocyte-derived macrophage (MDM) EVs in the development of HIV-associated PH MethodsEVs isolated from plasma of HIV-infected drug users and non-users with/without PH and from supernatants of HIV-infected MD...

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