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Safety and cardiovascular effects of multiple-dose administration of aripiprazole and olanzapine in a randomised clinical trial
2020-08-07
pharmacology and therapeutics
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ObjectiveTo assess adverse events and safety of aripiprazole and olanzapine treatment. MethodsTwenty-four healthy volunteers receiving 5 daily oral doses of 10 mg aripiprazole and 5 mg olanzapine in a crossover clinical trial were genotyped for 46 polymorphisms in 14 genes by qPCR. Drug plasma concentrations were measured by HPLC-MS/MS. Blood pressure and 12-lead ECG were measured in supine position. Adverse events were also recorded. ResultsAripiprazole decreased diastolic blood pressure on t...
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