Back

Structure of a type IV CRISPR-Cas effector complex

Zhou, Y.; Bravo, J. P. K.; Taylor, H. N.; Steens, J.; Jackson, R. N.; Staals, R. H. J.; Taylor, D. W.

2020-07-31 biochemistry
10.1101/2020.07.31.231399 bioRxiv
Show abstract

We reveal the structure of a type IV-B CRISPR effector (Csf) complex at 3.9 [A] resolution using cryo-electron microscopy. The complex resembles the type III-A CRISPR Csm effector complex, but lacks subunits for RNA processing and target DNA cleavage, and is surprisingly assembled upon heterogeneous non-CRISPR RNA. These findings provide the first glimpse into the assembly and function of enigmatic type IV CRISPR systems.

Matching journals

The top 4 journals account for 50% of the predicted probability mass.

1
Nature Communications
○ 5641 papers in training set
Top 3%
31.2%
Similar papers in this journal
2
Nature Structural & Molecular Biology
236 papers in training set
Top 0.6%
7.3%
3
eLife
● 5828 papers in training set
Top 17%
6.8%
Similar papers in this journal
4
Structure
○ 193 papers in training set
Top 0.3%
6.3%
Similar papers in this journal
50% of probability mass above
5
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 8%
5.5%
Similar papers in this journal
6
Communications Biology
○ 993 papers in training set
Top 3%
4.3%
7
Nature
○ 645 papers in training set
Top 4%
3.3%
8
Science Advances
● 1243 papers in training set
Top 10%
3.3%
9
Scientific Reports
○ 3612 papers in training set
Top 36%
2.8%
10
Journal of Biological Chemistry
○ 690 papers in training set
Top 5%
2.1%
11
Journal of Molecular Biology
○ 232 papers in training set
Top 2%
1.7%
12
Journal of Structural Biology
○ 64 papers in training set
Top 0.4%
1.7%
13
Life Science Alliance
● 285 papers in training set
Top 3%
1.7%
14
The EMBO Journal
○ 309 papers in training set
Top 4%
1.5%
15
Science
● 477 papers in training set
Top 6%
1.5%
16
Molecular Cell
○ 350 papers in training set
Top 4%
1.1%
17
Nucleic Acids Research
◐ 1281 papers in training set
Top 12%
1.0%
18
Biochemistry
● 148 papers in training set
Top 2%
1.0%
19
Acta Crystallographica Section D Structural Biology
● 59 papers in training set
Top 0.4%
1.0%
20
Scientific Data
○ 209 papers in training set
Top 3%
0.8%
21
F1000Research
○ 88 papers in training set
Top 4%
0.8%
22
Protein Science
○ 246 papers in training set
Top 4%
0.8%
23
PLOS ONE
● 5266 papers in training set
Top 62%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.