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Inhibitory KIR-Ligand Interactions and Relapse Protection Following HLA Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myelogenous Leukemia
2020-07-11
transplantation
Title + abstract only
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Killer immunoglobulin-like receptor (KIR) and KIR-ligand (KIRL) interactions play an important role in natural killer cell mediated graft versus leukemia effect (GVL) after hematopoietic stem cell transplant (HCT) for AML. Mathematically accounting for KIR-KIRL interactions may identify donors with optimal NK cell mediated alloreactivity and GVL. In this retrospective study of 2359 donor recipient pairs (DRP) who underwent unrelated donor (URD) HCT for AML, KIR-KIRL interaction scores were deter...
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