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Design and Development of Point of Care Test and Optical Reader for Early Screening of Kidney Related Disorder

Shivhare, P.; Mohla, S.; Dube, T.; Verma, A.; Srivastava, R.

2020-07-02 bioengineering
10.1101/2020.07.01.181024 bioRxiv
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Low-cost, paper-based colorimetric assays for early screening of albumin, creatinine and their ratio have been developed. The developed methods are noninvasive and require only 10µl of the urine sample. A reflectance-based optical reader has also been developed for the quantification of the albumin and creatinine. The developed method is based on spot urine testing which is advantageous when compared to the conventional 24-hour urine collection. The detection range of albumin and creatinine assays is 10-150 mg/dl and 25–400 mg/dl, respectively. The developed assays and optical reader were tested with the chronic kidney diseased patient’s samples at KEM Hospital, Mumbai.Competing Interest StatementThe authors have declared no competing interest.View Full Text

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