Back

Antifungal activity of 2,3-diphenyl-2,3-dihydro-1,3-thiaza-4-ones against two human pathogenic fungi

Liporagi Lopes, L. C.; Sobhi, H. F.; Silverberg, L. J.; Cordero, R. J.; Casadevall, A.

2020-06-27 microbiology
10.1101/2020.06.27.175711 bioRxiv
Show abstract

Invasive fungal diseases are prevalent in immunocompromised individuals in whom current therapies often provide suboptimal results. Additionally, the increased resistance to the available antifungal drugs necessitates a search for new compounds. This study reports the antifungal activity of six 5-, 6-, and 7-membered 2,3-diphenyl-2,3-dihydro-1,3-thiaza-4-ones against Lomentospora prolificans and Cryptococcus neoformans. Our data showed that some of the compounds tested had a low MIC and damage on the cell surface of the tested fungal species.

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

1
PLOS ONE
● 5266 papers in training set
Top 6%
23.4%
Similar papers in this journal
2
Antimicrobial Agents and Chemotherapy
● 187 papers in training set
Top 0.3%
10.2%
Similar papers in this journal
3
Scientific Reports
○ 3612 papers in training set
Top 13%
5.7%
Similar papers in this journal
4
Microorganisms
○ 106 papers in training set
Top 0.3%
4.5%
Similar papers in this journal
5
Molecules
○ 39 papers in training set
Top 0.2%
4.2%
Similar papers in this journal
6
Microbiology Spectrum
● 469 papers in training set
Top 4%
3.4%
50% of probability mass above
7
PLOS Neglected Tropical Diseases
● 466 papers in training set
Top 2%
3.4%
8
ACS Infectious Diseases
● 82 papers in training set
Top 0.5%
2.9%
9
Frontiers in Microbiology
○ 427 papers in training set
Top 4%
2.6%
10
International Journal of Antimicrobial Agents
○ 15 papers in training set
Top 0.2%
2.0%
11
ACS Omega
● 105 papers in training set
Top 1%
1.8%
12
Journal of Global Antimicrobial Resistance
○ 17 papers in training set
Top 0.3%
1.8%
13
Heliyon
○ 152 papers in training set
Top 4%
1.6%
14
Current Microbiology
○ 18 papers in training set
Top 0.4%
1.4%
15
International Journal of Molecular Sciences
○ 494 papers in training set
Top 10%
1.2%
16
Pathogens
○ 56 papers in training set
Top 0.8%
1.2%
17
Antibiotics
○ 34 papers in training set
Top 0.7%
1.2%
18
Fungal Ecology
○ 12 papers in training set
Top 0.1%
1.2%
19
Parasites & Vectors
○ 60 papers in training set
Top 1%
1.1%
20
Biomedicines
○ 67 papers in training set
Top 2%
1.1%
21
eLife
● 5828 papers in training set
Top 65%
0.9%
22
Journal of Microbiological Methods
○ 13 papers in training set
Top 0.4%
0.9%
23
Life Sciences
○ 27 papers in training set
Top 1%
0.9%
24
BMC Research Notes
○ 33 papers in training set
Top 1%
0.9%
25
Journal of Medicinal Chemistry
● 77 papers in training set
Top 0.9%
0.6%
26
Frontiers in Cellular and Infection Microbiology
○ 109 papers in training set
Top 4%
0.6%
27
Frontiers in Pharmacology
○ 111 papers in training set
Top 3%
0.6%
28
mBio
● 833 papers in training set
Top 12%
0.5%
29
Biomedicine & Pharmacotherapy
○ 42 papers in training set
Top 2%
0.5%
30
Microbial Pathogenesis
○ 17 papers in training set
Top 0.5%
0.5%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.