An agent based modelling approach to study lockdown efficacy for infectious disease spreads

We sought to simulate lockdown scenarios using an Agent Based Modelling (ABM) strategy, which is a new modelling paradigm that seeks to simulate the actions and interactions of autonomous agents within an environment. The spread of infectious viral diseases occur over a connected social network. Specifically, the goal was to understand the effect of network topology and lockdown strategies on disease spreading dynamics. To explore the effect of topology we assumed the social network over which the disease spreads to have small-world or scale-free properties characterized by a rewiring probability and degree distribution respectively. Lockdowns were simulated as intervention strategies that modified the spreading dynamics of infection over a given graph structure through changes in properties of agent interaction. Lockdown efficacy was assessed by the maximum number of infections recorded during a simulation run. Thereafter, lockdown efficacy was evaluated as a function of lockdown start times and duration. Thus, we propose that ABM approach can be used to assess various lockdown strategies that aim to prevent breakdown of medical infrastructure while accounting for realistic social network configurations specific to a local population. Notation O_TBL View this table: org.highwire.dtl.DTLVardef@ed3f5dorg.highwire.dtl.DTLVardef@1daf94corg.highwire.dtl.DTLVardef@1250312org.highwire.dtl.DTLVardef@ecae00org.highwire.dtl.DTLVardef@938aae_HPS_FORMAT_FIGEXP M_TBL C_TBL