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Rethinking antiviral effects for COVID-19 in clinical studies: early initiation is key to successful treatment
2020-06-03
infectious diseases
Title + abstract only
View on medRxiv
Show abstract
Development of an effective antiviral drug for COVID-19 is a global health priority. Although several candidate drugs have been identified through in vitro and in vivo models, consistent and compelling evidence for effective drugs from clinical studies is limited. The lack of evidence could be in part due to heterogeneity of virus dynamics among patients and late initiation of treatment. We first quantified the heterogeneity of viral dynamics which could be a confounder in compassionate use prog...
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