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Clinical characteristics and early outcomes in patients with COVID-19 treated with tocilizumab at a United States academic center

Rimland, C. A.; Morgan, C. E.; Bell, G. J.; Kim, M. K.; Hedrick, T.; Marx, A.; Bramson, B.; Swygard, H.; Napravnik, S.; Schmitz, J. L.; Carson, S. S.; Fischer, W. A.; Eron, J. J.; Gay, C. L.; Parr, J. B.

2020-06-13 infectious diseases
10.1101/2020.05.13.20100404 medRxiv
Show abstract

We describe early outcomes in 11 COVID-19 patients treated with the IL-6 receptor inhibitor tocilizumab. While C-reactive protein decreased, neither clinical improvement nor reduced temperature or oxygen requirements was observed in most patients. Our findings contrast with prior reports and raise questions about tocilizumab use in severe COVID-19.

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