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Pharyngeal carriage of inoculated recombinant commensal bacteria generates antigen-specific immunological memory

2020-05-10 infectious diseases Title + abstract only
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The human nasopharynx is colonized by commensal bacteria and pathobionts, which comprise a complex microbial ecosystem capable of generating primary and secondary immune responses. Experimental intranasal infection of human adults with the commensal Neisseria lactamica results in safe, sustained colonization. Herein is described a novel technology to chromosomally transform N. lactamica with heterologous antigen, for the purpose of safe delivery to the mucosal surface and the generation of an an...

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