Identifying the effect of vancomycin on HA-MRSA strains using bacteriological and physiological media
Rajput, A.; Poudel, S.; Tsunemoto, H.; Meehan, M.; Szubin, R.; Olson, C.; Seif, Y.; Lamsa, A.; Dillon, N.; Vrbanac, A.; Sugie, J.; Dahesh, S.; Monk, J.; Dorrestein, P.; Pogliano, J.; Nizet, V.; Feist, A.; Palsson, B. O.
Show abstract
Healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) USA100 strains are of major concern due to their evolving antibiotic resistant. They are resistant to a broad class of antibiotics like macrolides, aminoglycosides, fluoroquinolones, and many more. The selection of appropriate antibiotic susceptibility examination media is very important. Thus, we use bacteriological (CA-MHB) as well as physiological (R10LB) media to determine the effect of vancomycin on USA100 strains. The study includes the profiling behaviour of HA-MRSA USA100 D592 and D712 strains in the presence of vancomycin through various high-throughput assays. The US100 D592 and D712 strains were characterized at sub-inhibitory concentrations through growth curves, RNA sequencing, bacterial cytological profiling, and exo-metabolomics high throughput experiments. The study reveals the vancomycin resistance behavior of USA100 strains in dual media conditions using wide-ranging experiments.
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