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Pen-strep influence macrophage mechanical property and mechano-response to microenvironment

Zhao, W.; Hu, B.; Zhang, X.; Wang, P.

2020-04-11 biophysics
10.1101/2020.04.09.034884 bioRxiv
Show abstract

Penicillin-streptomycin (Pen-strep) is a common antibiotic used to prevent bacterial infection in cell culture and clinical treatment. Current research found pen-strep increased macrophage modulus but limited influence on cell adhesion. Phalloidin statin image indicates pen-strep mediate cell morphology on different extracellular matrix coated surface. The roundness analyzes further illustrated pen-strep promote cell spread on PDMS rubber, type I collagen, laminin, poly amino acid, poly-RGD peptides. Finally, YAP-1 and TAZ upregulation and {beta}1 integrin downregulation may be the causes of cell elasticity and mechano-response to extracellular matrix (ECM) change.

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