Oxygen-glucose deprivation and reoxygenation on human cerebral organoids alters expression related to lipid metabolism
Iwasa, N.; Matsui, T. K.; Morikawa, N.; Sakaguchi, Y. M.; Shiota, T.; Iguchi, N.; Nishimura, Y.; Mori, E.; Sugie, K.
Show abstract
Ischemic stroke is one of the most common neurological disease. However, the impact of ischemic stroke on human cerebral tissue remains largely unknown; due to a lack of ischemic human brain samples. In this study, we used cerebral organoids derived from human induced pluripotent stem cells to evaluate the effect of oxygen-glucose deprivation/reoxygenation (OGD/R). We identified 15 differentially expressed genes (DEGs); and found that all the DEGs were downregulated. Pathway analysis showed the relationship of vitamin digestion and absorption, fat digestion and absorption, peroxisome proliferator-activated receptor signaling pathway, and complement and coagulation cascades. These findings indicate the mechanisms underlying ischemic injury in human cerebral tissue.
Matching journals
The top 11 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Saxitoxin potentiates Zika virus-induced cell death in human neurons but not in neural progenitors and astrocytes 94%
- Human Cerebral Spheroids Undergo Activity Dependent Changes In Cellular Composition And MicroRNA Expression 93%
- Novel Adult Cortical Neuron Processing and Screening method illustrates Sex- and Age-dependent effects of pharmaceutical compounds 93%
Similar papers in this journal
- Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity 94%
- Non-viral derivation of induced pluripotent stem cells from the canine umbilical cord 94%
- Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors 94%
Similar papers in this journal
- Hypoxia induces early neurogenesis in human fetal neural stem cells by activating the WNT pathway. 97%
- Hotair and Malat1 Long Noncoding RNAs regulate Bdnf Expression and Oligodendrocyte Precursor Cells Differentiation 95%
- MicroRNA-502-3p modulates the GABA A subunits, synaptic proteins and mitochondrial morphology in hippocampal neurons 95%
Similar papers in this journal
- Stem cell factor and granulocyte colony-stimulating factor promote remyelination in the chronic phase of severe traumatic brain injury 95%
- Derivation of the immortalized cell line-UM51-PrePodo-hTERT and its responsiveness to Angiotensin II and activation of RAAS 93%
- Impaired p53-mediated DNA damage response contributes to microcephaly in Nijmegen Breakage Syndrome patient-derived cerebral organoids 93%
Similar papers in this journal
- Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells 95%
- NDR2 Kinase Regulate Microglial Metabolic Adaptation and Inflammatory Response: Critical Role in Glucose-Dependent Functional Plasticity 94%
- Physoxia influences global and gene-specific methylation in pluripotent stem cells 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.