Glucose extends lifespan through enhanced intestinal barrier integrity in Drosophila
Galenza, A.; Foley, E.
Show abstract
Dietary intervention has received considerable attention as an approach to extend lifespan and improve aging. However, questions remain regarding optimal dietary regime and underlying mechanism of lifespan extension. Here, we asked how glucose-enriched food extends the lifespan of Drosophila. We showed that glucose-dependent lifespan extension is independent of caloric restriction, or insulin activity, two established mechanisms of lifespan extension. Instead, we found that flies raised on glucose-enriched food increased the expression of cell junction proteins, and extended intestinal barrier integrity with age. Furthermore, chemical disruption of the intestinal barrier removed the lifespan extension associated with glucose-treatment, suggesting that glucose-enriched food prolongs adult viability by enhancing the intestinal barrier. We believe our data contribute to our understanding of intestinal health and may help efforts to develop preventative measures to limit the effects of aging and disease.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Muscle function and homeostasis require macrophage-derived cytokine inhibition of AKT activity in Drosophila 97%
- miR-125-chinmo pathway regulates dietary restriction dependent enhancement of lifespan in Drosophila 96%
- Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila 96%
Similar papers in this journal
- Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimers disease 94%
- From pathogen to commensal to probiotic: modification of Microbacterium nematophilum-C. elegans interaction during chronic infection by the absence of host insulin signalling 94%
- Stem cell-specific NF-kB is required for stem cell survival and epithelial regeneration upon intestinal damage. 94%
Similar papers in this journal
- Loss of Muscleblind Splicing Factor Shortens C. elegans Lifespan by Reducing the Activity of p38 MAPK/PMK-1 and Transcription Factors ATF-7 and Nrf/SKN-1 95%
- Gene-diet interactions: dietary rescue of metabolic defects in spen-depleted Drosophila 94%
- A pair of RNA binding proteins inhibit ion transporter expression to maintain lifespan 94%
Similar papers in this journal
- Piwi mutant germ cells transmit a form of heritable stress that promotes longevity 95%
- Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity 95%
- Lifespan and fecundity impacts of reduced insulin signalling can be directed by mito-nuclear epistasis in Drosophila 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.