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Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study
2020-03-20
epidemiology
Title + abstract only
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ImportanceEvidence on adiposity altering colorectal cancer (CRC) risk differently among men and women, and on metabolic alterations mediating effects of adiposity on CRC, is unclear. ObjectiveTo examine sex- and site-specific associations of adiposity with CRC risk, and whether adiposity-associated metabolites explain associations of adiposity with CRC. DesignTwo-sample Mendelian randomization (MR) study. SettingGenetic variants from expanded genome-wide association studies of body mass index...
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