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Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

2019-10-05 epidemiology Title + abstract only
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ObjectiveTo evaluate whether early life adiposity has an independent effect on later life disease risk or whether its influence is mediated by adulthood body mass index (BMI). DesignTwo-sample univariable and multivariable Mendelian randomization. SettingThe UK Biobank (UKB) prospective cohort study and four large-scale genome-wide association study (GWAS) consortia. Participants453,169 participants enrolled in the UKB and a combined total of over 700,000 individuals from different GWAS conso...

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