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Role of miRNAs induced by oxidized low-density lipoproteins in coronary artery disease: the REGICOR Study.
2019-08-02
cardiovascular medicine
Title + abstract only
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AimsCurrent risk prediction tools are not accurate enough to identify most individuals at high coronary risk. On the other hand, oxidized low-density lipoproteins (ox-LDLs) and miRNAs are actively involved in atherosclerosis. Our aim was to examine the association of ox-LDL-induced miRNAs with coronary artery disease (CAD), and to assess their predictive capacity of future CAD. Methods and resultsHuman endothelial and vascular smooth muscle cells were treated with oxidized or native LDLs (nLDL)...
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