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Source-linked multispecialty clinical reasoning and tumour-board decision-making in colorectal cancer

Gombolevskiy, V. A.; Sekacheva, M. I.; Sanikovich, V. D.; Bagmet, N. N.; Balaeva, D. A.; Nechaev, N. B.; Nesterov, A. I.; Bokov, A. A.; Panin, I. I.; Bespalov, I. R.; Gribakina, A. V.; Dylov, D. V.; Oseledets, I. V.

2026-10-21 oncology
10.64898/2026.10.19.26365647 medRxiv
Show abstract

Clinical records preserve patient findings and final recommendations but rarely capture how specialists select evidence, develop alternative interpretations, disagree, and converge on a management strategy. We describe a dataset derived from ten retrospectively selected, completed cases of histologically confirmed colorectal cancer. For each case, an administrator uploaded de-identified textual clinical records to an authenticated web-based annotation platform. A medical oncologist, surgical oncologist, and radiation oncologist, each with more than ten years of clinical experience, independently linked relevant source fragments to patient-specific interpretations and documented clinical problems, differential hypotheses, uncertainty, and diagnostic and treatment strategies. After the three records were locked, a large language model generated candidate questions for review by the tumour-board chair. The four physicians then discussed each case online; recordings were automatically transcribed and verified by two medical residents. The dataset comprises 30 source-linked specialist reasoning records, 10 verified case-level discussion transcripts, 10 final tumour-board decisions, and associated provenance and quality-control metadata. It supports research on evidence-grounded reasoning, cross-specialty disagreement, multidisciplinary decision-making, and multi-agent clinical decision support.

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