Coronavirus nucleocapsid proteins differentially antagonize RIG-I-like receptor signaling to shape pathogenicity
Rui, Y.; Wang, Y.; Chen, S.; Cao, Y.; Hu, Y.; Shen, S.; Ding, Q.; Su, J.; Yu, X.-F.
Show abstract
Coronaviruses cause human infections with divergent clinical outcomes. Viral proteins likely play important roles in the severity of human diseases but are poorly defined. In this study, we discovered that viral nucleocapsid (N) proteins from various human coronaviruses have distinct abilities to antagonize human innate immune responses. N proteins from more pathogenic coronaviruses, such as SARS-CoV and SARS-CoV-2, have more potent activities specifically against human RIG-I-like receptor (RLR) activation than less pathogenic coronaviruses including OC43 and HKU1. Mechanistically, the SARS-CoV-2 N protein interacts with RLR pathway viral RNA sensors MDA5 and RIG-I and inhibits their interaction with MAVS. The CTD of SARS-CoV-2 N protein is an important region for RLR antagonism. Consequently, N proteins from more pathogenic coronaviruses promote viral replication more effectively than N proteins from less pathogenic coronaviruses. Blocking N protein function may be a promising antiviral strategy.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- TRIM5α restricts flavivirus replication by targeting the viral protease for proteasomal degradation. 97%
- HCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication 96%
- Induction of an alternative 5’ leader enhances translation of Inpp5e and resistance to oncolytic virus infection 96%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus 96%
- Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation. 95%
- Redirection of SARS-CoV-2 to Phagocytes by Intranasal sACE2-Fc as a Universal Decoy Confers Complete Prophylactic Protection 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.