Epidemiology and virological characteristics of the emerging SARS-CoV-2 variant PJ.2.1
Hoffmann, M.; Zhang, L.; Chen, N.; Moor, N.; Nehlmeier, I.; Graichen, L.; Moldenhauer, A.-S.; Dopfer-Jablonka, A.; Happle, C.; Behrens, G. M. N.; Poehlmann, S.
Show abstract
SARS-CoV-2 continues to circulate globally at high levels and to evolve into new variants. Recently, a new saltation variant harbouring a highly mutated spike protein, PJ.2.1, emerged in North America. Here, we provide a brief epidemiological and virological characterization of PJ.2.1 and cocirculating variants. We report that PJ.2.1 is spreading in the USA, Canada, and Spain and mainly infects individuals aged 60 years and older, as do most other variants, with the exception of BA.3.2, which preferentially infects individuals aged 0-9 years. PJ.2.1 was less susceptible to inhibition by an antibody against ACE2 than were the other variants, indicating increased ACE2 binding. In contrast, PJ.2.1 did not show augmented evasion of antibodies from vaccinees who had received the LP.8.1-adapted vaccine compared with most other variants analysed. These results suggest that augmented ACE2 affinity rather than increased antibody evasion might drive the current, rapid spread of PJ.2.1.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France 94%
- Rapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations 93%
- Rapid Surge of Reassortant A(H1N1) Influenza Viruses in Danish Swine and their Zoonotic Potential 93%
Similar papers in this journal
- Emergence and spread of a sub-lineage of SARS-CoV-2 Alpha variant B.1.1.7 in Europe, and with further evolution of spike mutation accumulations shared with the Beta and Gamma variants 95%
- Genome data artifacts and functional studies of deletion repair in the BA.1 SARS-CoV-2 spike protein 94%
- Intra-host evolution during SARS-CoV-2 persistent infection 94%
Similar papers in this journal
- Longitudinal Study after Sputnik V Vaccination Shows Durable SARS-CoV-2 Neutralizing Antibodies and Reduced Viral Variant Escape over Time 94%
- Population immunity to clade 2.3.4.4b H5N1 is dominated by anti-neuraminidase antibodies 94%
- Imprinted anti-hemagglutinin and anti-neuraminidase antibody responses after childhood infections of A(H1N1) and A(H1N1)pdm09 influenza viruses 94%
Similar papers in this journal
- Neutralization of ancestral SARS-CoV-2 and variants Alpha, Beta, Gamma, Delta, Zeta and Omicron by mRNA vaccination and infection-derived immunity through homologous and heterologous variants 95%
- Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel 94%
- Qualitatively distinct modes of Sputnik V vaccine-neutralization escape by SARS-CoV-2 Spike variants 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.