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Intelligence and the Big Five personality traits share a genetic and biological basis

Buonaccorsi, A. C.; DeYoung, C. G.; Maher, D.; Edwards, T.

2026-09-30 genomics
10.64898/2026.09.30.755709 bioRxiv
Show abstract

Intelligence is often considered to be fundamentally different from other personality traits. Twin studies show that intelligence and the Big Five personality traits are partly influenced by the same genetic factors, but it remains unclear to what degree shared genes, SNPs, and biological pathways influence them. To address these questions, we analyzed the genetic associations of all six traits. First, we calculated their genetic correlations using LD score regression. We then quantified polygenic overlap using a bivariate causal mixture model, finding that approximately 90% of the genetic variants influencing the Big Five personality traits also impact intelligence. Finally, we performed gene prioritization and gene set enrichment analysis on each trait, once again finding substantial overlap. At each level, intelligence was as similar to the Big Five traits as they were to one another. Genetically and biologically, intelligence fits in with the rest of personality.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.