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Bone Marrow-Derived Cells Fuse with Bergmann Glia in Experimental Autoimmune Encephalomyelitis

Tellez de Meneses, P. G.; Sanchez-Monreal, S.; Avila-Zarza, C. A.; Escudero-Solano, C.; Weruaga, E.; Diaz, D.; Valero, J.; Alonso, J. R.

2026-10-06 neuroscience
10.64898/2026.09.29.755471 bioRxiv
Show abstract

Bone marrow-derived cells (BMDCs) can infiltrate the brain and adopt new identities through transdifferentiation or fusion, yet their interactions with specific neural cells remain poorly defined. We examined BMDC fusion with Bergmann glia (BG), a key cerebellar support cell, in a mouse model of multiple sclerosis. After bone marrow transplantation, BMDCs fused with BG to form heterokaryons, retaining BG morphology and molecular markers. These heterokaryons contained donor and host nuclei that differed in both morphology and transcriptional activity. Remarkably, the BMDC nucleus localized not only to the soma but also along BG processes. This discovery identifies BMDC-BG fusion as a previously unrecognized form of glial plasticity, opening avenues for therapeutic strategies aimed at potentiating glial-mediated repair.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.