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Awake sharp-wave ripples coincide with rhythmic cortical synchronization

Lim, T. H.; Zhang, X.

2026-09-30 neuroscience
10.64898/2026.09.29.754885 bioRxiv
Show abstract

Analysis of the Allen Institute Visual Coding Neuropixels dataset revealed a ~5 Hz synchronization of visual cortical activity in awake, immobile mice. During bouts of this rhythm, synchronized cortical bursts coincided with changes in the occurrence of sharp-wave ripples (SWRs) and dentate spikes and in SWR properties. Cortical synchronization, SWRs, and dentate spikes were also coordinated with slower pupil-size fluctuation, revealing that awake SWRs are embedded within nested brainwide rhythms.

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