Ciliary regulation of melanogenesis unveils moonlighting roles for Joubert Syndrome proteins
Magne, B.; Forsey, S.; Harper, D. C.; Zhang, J.; Snider, C. E.; Feng, Y.; Tishkoff, S. A.; Strong, A.; Drivas, T. G.; Goding, C. R.; Lee, R. J.; Marks, M. S.
Show abstract
We previously found that skin tone correlates with intronic polymorphisms influencing the expression of the Joubert Syndrome (JS) ciliopathy gene TMEM138, suggesting that primary cilia might regulate pigment production in skin melanocytes. Herein, we show that many ciliary proteins regulate basal pigmentation in wild-type mouse and human melanocytes by facilitating primary cilium-dependent Melanocortin-1 receptor signaling, and downstream activation of the Microphthalmia transcription factor and melanogenic gene expression. Additionally, we identify an extra-ciliary moonlighting role for TMEM138 and other JS proteins in endolysosomal organization required for the biogenesis of melanosomes, the pigment-producing lysosome-related organelle in melanocytes. Our results provide new mechanistic insights into the physiological regulation of pigmentation and suggest that JS-specific pathology might be mediated by ciliary-independent mechanisms.
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