The claustrum encodes and scales appetitive feeding
de Almeida, C.; Mashhour, N.; Bertrand, B.; Ansoult, A.; Castel, J.; Luquet, S.; Gangarossa, G.
Show abstract
The claustrum regulates reward processing, but its role in feeding remains unknown. We report that palatable food recruits claustral neurons and a claustrum-to-medial prefrontal cortex circuit whose activation reduces high-fat diet intake. These findings identify the claustrum as a key regulator of appetitive feeding, with potential implications for metabopsychiatric disorders.
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