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Genetic background influences cocaine neuroplasticity in the accumbens shell of male mice
Nwakama, C. A.; Chapp, A. D.
2026-09-28
neuroscience
10.64898/2026.09.21.753182
bioRxiv
Show abstract
Genetics shape cocaine behavior and abuse liability, but the underlying neurophysiological effects remain understudied. In male C57BL/6J, B6129SF2/J, and DO/J mice, we report conserved and divergent cocaine induced neuroplasticity in the accumbens shell following 5 days of cocaine and 10 to 14 days of abstinence.
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