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CytosMPS: an automated multimodal pooled screening platform for protein, morphology and transcriptomics

Lopez, T.; Rabalais, J.; Song, B.; Boddicker, A.; Schwartz, A.; Honigfort, D.; Zhao, J.; Kellinger, M.; Kruglyak, S.

2026-09-24 cell biology
10.64898/2026.09.20.752925 bioRxiv
Show abstract

Cytos Multimodal Pooled Screening (CytosMPS) measures CRISPR guide identity, morphology, native 3' transcriptome, and protein abundance and localization in the same fixed cells. Following IL-1{beta} stimulation, cells with higher nuclear NF-{kappa}B show lower phospho-p38/HSP27 and higher NFKBIA/DUSP1 in the same cell, a measurement neither imaging nor transcriptomics alone provides. TGFBR2 and CTNNB1 perturbations produce distinct multimodal phenotypes. Guide representation and perturbation transcriptional responses agree with an orthogonal single-cell transcriptomic platform.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.