Bacterial lipid effectors subvert host autophagic flux by inducing lysosomal dysfunction
PIN, C.; MARRAULD, C.; BRANCHU, P.; BONNART, C.; ROLLAND, C.; LOBJOIS, L.; LACHAMBRE, S.; TAIEB, F.; Oswald, E.; DAVID, L.
Show abstract
HlyF and CprA, virulence factors from Escherichia coli and Pseudomonas aeruginosa respectively, constitute a previously unrecognized family of cytoplasmic enzymes that drive virulence through the production of outer membrane vesicles (OMVs) enriched in toxic bioactive lipids. Here, we show that OMVs of bacteria producing HlyF/CprA impair host autophagic flux by targeting lysosomal function. Specifically, these OMV-associated lipids disrupt autophagosome-lysosome fusion and induce hallmark features of lysosomal dysfunctions, including defective acidification, cholesterol accumulation, and membrane permeabilization. These lipid-mediated alterations compromise lysosomal integrity and block autophagic degradation. Our findings reveal a novel mechanism by which bacterial lipids subvert lysosomal functions and host clearance pathways. Given the widespread expression of HlyF/CprA homologs across diverse pathogens, this work highlights lipid effectors as key determinants of pathogenesis.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin 95%
- Origin of Eukaryotic Plasmalogen Biosynthesis by Horizontal Gene Transfer from Myxobacteria 94%
- FliO is an evolutionarily conserved yet diversified core component of the bacterial flagellar type III secretion system 94%
Similar papers in this journal
Similar papers in this journal
- Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery 95%
- Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C 93%
- The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.